Remember that horrible scene in Event Horizon, in which an astronaut has to float through the total vacuum of space without a space suit?
In the video below, a man is actually exposed to a total vacuum, as the result of an accident during a NASA test with a vacuum chamber in 1965. He lived to tell the tale.
From the NASA website:
At NASA’s Manned Spacecraft Center (now renamed Johnson Space Center) we had a test subject accidentally exposed to a near vacuum (less than 1 psi) in an incident involving a leaking space suit in a vacuum chamber back in ’65. He remained conscious for about 14 seconds, which is about the time it takes for O2 deprived blood to go from the lungs to the brain. The suit probably did not reach a hard vacuum, and we began repressurizing the chamber within 15 seconds. The subject regained consciousness at around 15,000 feet equivalent altitude. The subject later reported that he could feel and hear the air leaking out, and his last conscious memory was of the water on his tongue beginning to boil.
Here’s a nice list with movie depictions of people exposed to total vacuum, including 2001: A Space Odyssey and Total Recall.